What does it mean if a no-cd or fixed exe works w/orig disc?

[Dazzl]

I realize that this is a newbie question but indulge me please.

If I successfully install a protected game on my rig but it won't run, just a splash screen and then nothing....

I then find a no-cd or fixed exe on this fantastic site, and this file works and allows me to play the game does this mean that my problem was caused by the protection?

Again I know this is a dumb question but I am having this issues pop up over and over but as yet do not understand why.

Thank you for any replies, in advance.

Dazzl: