Hard to be a God freezes

[wolfsrain]

I Have the same CPU as you, an X-Fi sound card, 4gb RAM, Asus 8600GTS, Gigabyte P35 S3. So that's pretty close of what you got from many points of view.
Didin't had problems at all. My main problem was before Hard to be a God. I've had crashes frequently, until I've discovered that it was Bios related, as the Bios had some problems with PS2 keyboards. Try updating the Bios also. Check on MSI site. Hopefully you know how to update the MB Bios.
If even after that, you still have problems, maybe you need a HDD format(at least on the OS partition, if you have partitioned your HDD) and a clean OS reinstall(XP/Vista)