Bit of help making backups?

[OverDose]

I have cloneCD 3.3.4.1 with "amplify weak sector" option enabled and the following cd rom devices:

AOpen DVD1648/AMH firmware revision R13
Iomega/Plextor 12x10x32a firmware revision 1.09

I need some basic options and defaults for backing up games into an image that would work successfully without any hangups, I need to know which drive is better to use and just some basic knowledge

Thanks in advance.