Tips for .exe patching compressed TCS Engine 2.0+ titles?

[L33THAK0R]

As the title suggests I've been trying to find information about how to patch the .exe of games using TCS Engine 2.0+ (2011 - ). The most notable games that use this engine and newer are post 2011 LEGO games. From what little I've been able to find on this forum there isn't a universal solution to patching the .exe as the method changes on each title and version of said title. Any help would be greatly appreciated.