[bOOls eYe]

I don't think Safedisc searches registry entries of debuggers.
SoftIce is installed on my computer, but it's not loaded now (I disabled it in my autoexec.bat), and I can perfectly run SD protected games.
If SoftIce is loaded, pressing Ctrl-D will take you to its main window (press Ctrl-D again to quit). If nothing happens, SI is not loaded.

FrogsIce will work with SD 1.xx.xx, but not with SD2.
If both SoftIce and FrogsIce are loaded, and you try to run a SD2 protected exe, the message 'Unload the debugger and try again' will NOT appear ! It will just quit, even before the cd-check.

Another debugger is TRW. If this program is loaded, SD2 will refuse to run too (I'm not 100% sure about that, as I always work with SoftIce).

themis_t, I think you mean 'Icepatch' as that alternative for FrogsIce...

Have a look at your autoexec.bat file to see if a debugger is loaded during startup.

If the message still appears, I suggest to mail to Macrovi$ion, not to the game developers.

Hope this helps,