I have created the .bin image from an original copy of NHL2001 and when I try to apply the patch using patchwiz ####://www.darksouls.co.uk/ I get the bin file is not the expected size error.
ANSWER: That one's easy - the patch was not created from the same version as the one you copied.
Have I set up CDRWIN up wrong I used the following settings in exratc image
1

isc/Image Cuesheet
correct
2:RAW
correct
3:Error Recovery - Ignore
wrong should be Abort
4

ata Speed - 2x
neutral
5:Audio Speed - 2x
neutral
6:Retry count - 50
neutral
Why do you need to patch it? CloneCD is a better way of copying it unless there is an over-riding need to patch it.