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you have ALL the pre-requisites installed, from the ISSetupPrerequisites folder?
Microsoft .NET Framework 3.5 SP1.prq
Microsoft DirectX Redist (June 2010).prq
Microsoft Visual C++ 2008 SP1 Redistributable Package (x86).prq
Rockstar Games Social Club.prq
from the readme on disk
"Other Requirements:
Initial game and DLC activation requires an internet connection.
L.A. Noire PC requires the installation of software and components including GameShield
IronWrap & Patcher;DirectX, and Microsoft’s Windows .NET Framework, and
Microsoft Visual C++ 2008 SP1 Redistributable Package (x86)."
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