I have a problem running ISS pro 2 as well, i'm using PS-X-change CD instead of the internalmodchip.

The CD copy of the game plays , i see the graphics and the sound is ok , but the picture is not adjusted , it keeps moving vertically
(as an Video tape needs tracking), the colors are not good though.
i don't know what seems to be the problem. by the way the PS-X_CHANGE CD plays the orginal as well with the same result mentioned above. Please some body help us on this issue.