GCW info for Mass Effect:

"This game does not require the DVD to be present after the game has been activated with a valid/legal serial. So a Fixed EXE is not needed!"

This is completely wrong!

There are Czech version (CD Projekt release) with SafeDisc and Russian version with StarForce.
Both require no internet activation but require DVD in drive to play! I've been searching Online shops for Czech version to buy just because of this...(from info I gathered you can select and play that version in English)