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Well... U should have a look what the original is about, though.
Throw in the original disc. Will the installer run? Yes? Well, than is your image for some way damaged. Then simply recreate the image and you´re done. (But u shouldn´t use iso* format as it is not capable to store copyprotection relevant data, and as far as I remember the bioshock installer verifies the disc directly after install, so an iso won´t work for this game in any case).
When the original also refuses to install/run there might be some bug in some circumstances. Then U might ask the publisher´s forum for help.
That´s the way u should start to analyze ur problem.
GRx
* Google Alcohol120% or DaemonToolsProAdvanced
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