If you can't start the game, it won't be an NTSC/PAL problem - at worst it would play black and white but it would play if it was going to boot at all.

So one has to look at the source of your game.
Was it downloaded? (Some/many downloads are dodgy).
What files exactly were downloaded after extraction?
What burning method and paramaters and speed were used for burning?
Same question if you were copying from an original?