Hey all,
I (think) I found a fix for RS:V. It worked for me at least. I'm running the game with all the latest patches and whatnot.
1. Run YASU
2. Settings > Device Manager > Disable CD/DVD Drive
3. Mount Original MDS in Daemon tools
4. ...wait for load...click play.
5. Play!
Sorry if this has already been figured out, just thought i'd share