Beginning with version 4.5 Safedisc protected titles can only be started with a full or maxi image (maybe this should be mentioned in the FAQ).
You also have to use an anti-blacklisting tool like Pr0t.St0p, to avoid detection of your optical IDE drive(s).
Maybe you also have to change the 'installation path' in registry (or reinstall from mounted image).
btw.
http://www.fileforums.com/showthread.php?t=76504