ok guys, i found a solution that works very well for me:
-first i de-installed TQ completely
-re-installed it
-the only emu software a have installed is DaemonTools 4.03 with alle emulations on
-than i installed CureROM Pro v2.0.3 (creating a TQ profile with the built in wizard is quit easy)
-i used the mini-image from Bender
-so i let do curerom all the work, starting the game, mounting the image and so on
-at least i have deleted the video folder from TQ
-started up the game with the shortcut created by curerom
-putting all options to default (dont know if this is important to run the game smooth)
-so the fact is i played the game the whole day without a single crash
dont know if this works for others
i can upload my curerom-profile, if this will help in anyway