This is only a Guess
But when you install a game from CD or DVD (Or from anywhere)
In the Registry somewhere (Not sure of this Game as I don't Have it) there is or I would of thought that there would be a location for seeing the CD or DVD Drive's & I would guess that if its missing or been deleted then the Game will ask for the Disc again, I have only ever something like that happen to me 1once.
Sometimes the best way to find out if thats the case is to put your disc in the Drive again & see in the Game's
Autorun Menu of the Installer
Display window, if you see an Option like
Play if not then something is wrong.
TIP:
Have you used any Utilities like Reg cleaners etc...
Anyway hope it helps