I had this message time & time again (A required security module couldn't be activated), I tried Antiblax at first (ver 116) and then Virtual CD hide and the "Setting Win2k Compatability mode" , finally, i traced my problem to having been running Slysoft's AnyDVD at startup, as soon as i shut this program down, Bingo, i was rewarded with the familiar silver spinning disk icon of Securom and the game ran fine!
This one seems very picky as to what you are running, i don't agree with the fact that certain programs should be removed (blacklisted) in order to run other's, Especially dealing with damageable media such as CD's / DVD's...
