Was just checking all the bases, there are stupid people out there
Anyway...have you tried running the original on the second machine to see if it works - it may be that there is a program installed on that machine that is blacklisted by Macrovision - so when you try to start a SD game (even with original), if it detects such programs it refuses to start.
Daemon Tools, Playbackup, Insektors? If so, uninstall them or look for an update.