Have a look around at
www.gamecopyworld.com or
www.megagames.com for a no-cd crack.
If you can't find one for your game then you could try downloading Alcohol 120% and creating an image of the game onto your hard drive - you can then 'mount' this image onto a virtual drive using Alcohol 120%. This will act like a normal cd-rom so you can put your original cd away.