PTR, try turning the volume up on your PC
Seriously though.... have you copied all media (sounds & movies) from the cd to the hard drive? You sure, that in the in-game options, that the sound settings are set to full (or to your own tastes)?
Perhaps it is not possible to make an 'official' NoCD crack for this game, the gimps have not made one and cdkiller tried.
You could just make an image to your hard drive, and then play the game from that. Wait for Rincewind to post the exact procedure, or search for his posts.