Hi All.
I have experienced the same error message when trying to run my original copy of Sid Meier's Sim Golf. It has been very frustrating trying to solve the problem, but with a combination of some of the information on this thread and a bit of though, I was lucky enough to come across a solution. Well, it worked on my machine at least.
I am running XP Professional with a host of software, including a bunch of trial software. I also run Norton Anti-Virus.
1) Disable Norton AntiVirus
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I have disabled Norton by running 'msconfig' and disabling navpw32 under the Startup tag. I also disabled 'Norton AntiVirus Auto Protest Service' under the Services tag.
2) Remove amdfix.sys
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I got this one from you guys. I have renamed it to a .bak file. I tried this at the beginning, however it didn't seem to work. All that happened is that the message went away, but when I ran the game, a task appeared in my task bar but nothing ever ran. It did work though after step 3 below.
3) Run Ad-aware to remove spyware
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I was struggling to figure out what debuggers or similar services may be running. I then found a tool at
http://www.lavasoftusa.com/aaw.html called Ad-aware. What it does is it identifies any advertising spyware that is installed on you machine and removes it for you.
After these three steps, my game finally works.
I hope this helps and good luck.
Derf.