what software?
 

I have a lite-on 40125s re-writer and a mat****a dvd rom sr-8583

which is the best software to back up a ps2 game
clone cd can't do it somehow?

my Liteon drive works fine with CloneCD, follow the tutorials from the sticky post at the top of this forum section.

you will only be able to backup CD based games using this setup (or make ripped backups of DVD based games)