I think you mean Neo and yes it will. If your not sure how to boot games check out the boot procedures sticky.

Here is the Neo 2.2 boot procedures........

Normal Boot Method (PS2 Backups)

That standard method for PS2 backups using AR2/GS2
• Insert the AR2/GS2 CD1
• Power off the PS2 for 5 seconds
• Turn on the machine - will boot to a menu
• Select START GAME
• Select WITHOUT CODES
• Press Eject
• Swap AR2/GS2 disc with your PS2 backup
• Press eject to close tray
• Press X AS SOON as the tray closes
• The game will now load

Alternative Boot Method (PS2 Backups & AR2/GS2 v1.1)

NOTE: This alternative method has had greater success with v1.1 AR2/GS2

• Insert the AR2/GS2 CD1
• Power off the PS2 for 5 seconds
• Turn on the machine - will boot to a menu
• Select START GAME
• Select WITHOUT CODES
• Screen will say Insert Disc - Press X
• Press Eject
• Swap AR2/GS2 disc with your PS2 backup
• Press X - Wait for it to say Loading and background animation stops
• Press eject to close tray
• The game will now load

EA Boot Method (PS2 Backups)

NOTE: This is the method for PS2 backups that won't boot with normal method.

• Insert the AR2/GS2 CD1
• Power off the PS2 for 5 seconds
• Press and hold the reset button - machine will boot
• Menu screen will appear
• Select START GAME (Still holding Reset)
• Select WITHOUT CODES (Still holding reset)
• Let go of reset - tray will eject and stay open for 4 seconds
• The disc will still be spinning when using AR2/GS2 v1.4 & above
• Swap AR2/GS2 disc with your PS2 backup
• Do not press eject - the tray will close automatically
• Press X AS SOON as the tray closes
• For AR2/GS2 v1.4 & above you need to select O + R1 instead of X
• The game will now load

You also have the option to patch your EA game.

EA Boot Method 2 (PS2 Backups)

NOTE: This is the alternative EA Method that seems to work for some people.

• Insert the AR2/GS2 CD1
• Power off the PS2 for 5 seconds
• Press and hold the reset button - machine will boot
• Menu screen will appear
• Let go of reset - tray will eject and stay open for 4 seconds
• The disc will still be spinning when using AR2/GS2 v1.4 & above
• Leave the AR2/GS2 disc in and let the tray close
• Select START GAME
• Select WITHOUT CODES
• Press Eject
• Swap AR2/GS2 disc with your PS2 backup
• Press Eject - Game will now load
• Press X
• If you have v1.4 & above you may need to press O + R1 instead of X
• The game will now load

You also have the option to patch your EA game.

DVD Rip Boot Method (PS2 DVD Rips)

NOTE: Another alternative method for troublesome discs.

• Insert the AR2/GS2 CD1
• Power off the PS2 for 5 seconds
• Press and hold the reset button - machine will boot
• Menu screen will appear
• Let go of reset - tray will eject and stay open for 4 seconds
• The disc will still be spinning when using AR2/GS2 v1.4 & above
• Swap AR2/GS2 disc with your DVD Rip backup
• Select START GAME
• Select WITHOUT CODES
• Press eject till tray comes out halfway then press eject again
• Press X AS SOON as the tray closes
• For AR2/GS2 v1.4 & above you need to select O + R1 instead of X
• The game will now load

Ready to Rumble 2 Boot Method (Alternative Method)

NOTE: Some people had trouble with Ready to Rumble 2 and this seemed to fix it.

• Use the normal EA Boot Method to boot the game
• As soon as the game starts to check the Memory Card Press EJECT
• Wait a couple of seconds until the main R2R screen appears
• Close the tray and the game should now work ok

Booting Playstation 1 backups & Playstation 2 originals

Wouldn't it be great if all backups booted like this !

• Power off the PS2 for 5 seconds
• Boot as normal - no special method

How to boot Playstation 1 originals

NOTE: This technique simply deactivates the chip

• Insert your PSX original
• Power off the PS2 for 5 seconds
• Press reset for 1 second (Until blue light comes on) then let go
• Game will now boot as normal - the chip is deactivated

How to boot PSX imports

• Insert your PSX original
• Power off the PS2 for 5 seconds
• Turn on the machine
• Press eject just before the PSX LOGO SCREEN
• Swap with your PSX import backup
• Press eject to close the tray
• The game will now load

How to boot DVD-R (only) with AR2/GS2 V2x

Thanks to Nightstalker for this method!

• Insert AR2/GS2
• Power down console, wait 5 sec, and restart console by pressing and holding reset. (Dont let go)
• After GS2 completely loads, swap with original dvd game.(high TOC)
• Wait about 15 sec and select Gameshark codes (or ar2 codes) and turn on or off any code on any game.
• Press start, select with codes and press x to load game.
• You will see a black screen saying "updating codes please wait" at this time release the reset button, tray will eject, swap with backup, tray closes and game loads.